Process for the preparation of oseltamivir and methyl 3-epi-shikimate,Council Of Scientific & Industrial Research, INDIA

New Drug Approvals

File:Oseltamivir.svg

oseltamivir

Process for the preparation of oseltamivir and methyl 3-epi-shikimate, for Influenza virus infection

WO 2013061340

BY

Rawat, Varun; Dey, Soumen; Arumugam, Sudalai

The present invention discloses high yielding enantioselective process for synthesis of Oseltamivir from readily available starting material, cis-1,4-butene diol.The process features incorporation of chirality using sharpless asymmetric epoxidation(AE) and diastereoselective Barbier allylation and construction of cyclohexene carboxylic acid ester core through a ring closing metathesis (RCM) reaction. Further also disclosed herein is synthesis of (-)-methyl 3-epi-shikimate.

http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=

20130502&CC=WO&NR=2013061340A1&KC=A1

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